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Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171437, updated on 17-Aug-2024

Summary

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Official Symbol
Dnttip1provided by RGD
Official Full Name
deoxynucleotidyltransferase, terminal, interacting protein 1provided by RGD
Primary source
RGD:621627
See related
EnsemblRapid:ENSRNOG00000014933 AllianceGenome:RGD:621627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; nucleosome binding activity; and protein homodimerization activity. Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human DNTTIP1 (deoxynucleotidyltransferase terminal interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 92.6), Testes (RPKM 78.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnttip1 in Genome Data Viewer
Location:
3q42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173901070..173924742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153481718..153505403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161212156..161235749)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene WAP four-disulfide core domain 3 Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast skeletal type

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The oncofetal protein p65: a new member of the steroid/thyroid receptor superfamily. Hanausek M, et al. Cancer Detect Prev, 1996. PMID 8706045
  2. Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. Itoh T, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25653165, Free PMC Article
  3. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. Yamashita N, et al. Genes Cells, 2001 Jul. PMID 11473582
  4. Direct binding of TReP-132 with TdT results in reduction of TdT activity. Fujisaki S, et al. Genes Cells, 2006 Jan. PMID 16371131
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124886

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone deacetylase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
deoxynucleotidyltransferase terminal-interacting protein 1
Names
tdIF1
tdT-interacting factor 1
terminal deoxynucleotidyltransferase-interacting factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134400.2 → NP_599227.2  deoxynucleotidyltransferase terminal-interacting protein 1

    See identical proteins and their annotated locations for NP_599227.2

    Status: VALIDATED

    Source sequence(s)
    BC100640
    UniProtKB/Swiss-Prot
    Q91Y53
    UniProtKB/TrEMBL
    Q497A7
    Related
    ENSRNOP00000103422.1, ENSRNOT00000162591.1
    Conserved Domains (1) summary
    pfam18192
    Location:65 → 132
    DNTTIP1_dimer; DNTTIP1 dimerisation domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    173901070..173924742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104212.2 → XP_038960140.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    pfam18192
    Location:65 → 125
    DNTTIP1_dimer; DNTTIP1 dimerisation domain

  2. XM_039104210.2 → XP_038960138.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q91Y53
    Related
    ENSRNOP00000108339.1, ENSRNOT00000150206.1
    Conserved Domains (1) summary
    pfam18192
    Location:65 → 132
    DNTTIP1_dimer; DNTTIP1 dimerisation domain

  3. XM_039104211.2 → XP_038960139.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q91Y53
    Conserved Domains (1) summary
    pfam18192
    Location:25 → 92
    DNTTIP1_dimer; DNTTIP1 dimerisation domain

RNA

  1. XR_005501766.2 RNA Sequence

  2. XR_005501767.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Y53.1 GenPept UniProtKB/Swiss-Prot:Q91Y53

Gene LinkOut

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