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Ipmk inositol polyphosphate multikinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 171458, updated on 2-Nov-2024

Summary

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Official Symbol
Ipmkprovided by RGD
Official Full Name
inositol polyphosphate multikinaseprovided by RGD
Primary source
RGD:620954
See related
EnsemblRapid:ENSRNOG00000000609 AllianceGenome:RGD:620954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Impk; Ipk2
Summary
Enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity and inositol phosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process; inositol trisphosphate metabolic process; and necroptotic process. Predicted to act upstream of or within neural tube formation. Located in nucleus. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 167.5), Lung (RPKM 48.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ipmk in Genome Data Viewer
Location:
20p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (17216151..17250826, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (17216988..17251675, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (18457309..18489884, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483788 Neighboring gene uncharacterized LOC102547881 Neighboring gene ribosomal protein L39, pseudogene 14 Neighboring gene CDGSH iron sulfur domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Saiardi A, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226235, Free PMC Article
  2. An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. Frederick JP, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15939867, Free PMC Article
  3. Dvl3 translocates IPMK to the cell membrane in response to Wnt. Wang Y, et al. Cell Signal, 2012 Dec. PMID 22940627, Free PMC Article
  4. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. Gu C, et al. J Med Chem, 2019 Feb 14. PMID 30624931, Free PMC Article
  5. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Resnick AC, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123124, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Translocation of IPMK to plasma membrane via docking Dvl3 is important for IPMK to access substrates and generate IP5, activating down-stream signaling.
    Title: Dvl3 translocates IPMK to the cell membrane in response to Wnt.
  2. IPK2 and IPK1 act as key determining steps in production of IP5 and IP6, respectively
    Title: A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavonoid binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5-trisphosphate 6-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
inositol polyphosphate kinase 2
NP_599244.1
XP_006256407.1
XP_006256408.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134417.2 → NP_599244.1  inositol polyphosphate multikinase

    See identical proteins and their annotated locations for NP_599244.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    Q99NI4
    UniProtKB/TrEMBL
    A0A8I6AI58, A6JKN6
    Related
    ENSRNOP00000093022.2, ENSRNOT00000105838.2
    Conserved Domains (1) summary
    pfam03770
    Location:110 → 391
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    17216151..17250826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256345.5 → XP_006256407.1  inositol polyphosphate multikinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI58, A0A8L2PZ63
    Related
    ENSRNOP00000000748.3, ENSRNOT00000000748.5
    Conserved Domains (1) summary
    pfam03770
    Location:111 → 392
    IPK; Inositol polyphosphate kinase

  2. XM_006256346.5 → XP_006256408.1  inositol polyphosphate multikinase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AI58
    Conserved Domains (1) summary
    pfam03770
    Location:69 → 350
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NI4.1 GenPept UniProtKB/Swiss-Prot:Q99NI4

Gene LinkOut

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