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Stau2 staufen double-stranded RNA binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171500, updated on 10-Oct-2024

Summary

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Official Symbol
Stau2provided by RGD
Official Full Name
staufen double-stranded RNA binding protein 2provided by RGD
Primary source
RGD:621479
See related
EnsemblRapid:ENSRNOG00000042458 AllianceGenome:RGD:621479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including Hsp70 protein binding activity; kinesin binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Part of messenger ribonucleoprotein complex. Used to study microphthalmia. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 204.5), Heart (RPKM 102.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stau2 in Genome Data Viewer
Location:
5q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (7623528..7868206)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (2840741..3084935)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2257910..2497429)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2W Neighboring gene spindlin-2-like Neighboring gene uncharacterized LOC134486907 Neighboring gene uncharacterized LOC102555040 Neighboring gene uncharacterized LOC134486911 Neighboring gene retinol dehydrogenase 10 Neighboring gene ribosomal protein L7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons. Fernández-Moya SM, et al. Int J Mol Sci, 2021 Dec 1. PMID 34884825, Free PMC Article
  2. Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats. Berger SM, et al. Genome Biol, 2017 Nov 17. PMID 29149906, Free PMC Article
  3. Staufen2 regulates neuronal target RNAs. Heraud-Farlow JE, et al. Cell Rep, 2013 Dec 26. PMID 24360961
  4. The double-stranded RNA-binding protein Staufen 2 regulates eye size. Cockburn DM, et al. Mol Cell Neurosci, 2012 Nov. PMID 22940085
  5. Genome wide identification of Staufen2-bound mRNAs in embryonic rat brains. Maher-Laporte M, et al. BMB Rep, 2010 May. PMID 20510018

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons.
    Title: RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons.
  2. RBP Stau2 plays an important role in the regulation of specific aspects of hippocampal synaptic plasticity and learning and memory.
    Title: Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats.
  3. results identify the retained intron as a critical element in recruiting Stau2, which then allows for the localization of Calm3L mRNA to distal dendrites
    Title: A retained intron in the 3'-UTR of Calm3 mRNA mediates its Staufen2- and activity-dependent localization to neuronal dendrites.
  4. Here, we describe a new role for the ATP-dependent helicase UPF1 and its interaction with the RNA localization protein STAU2 in mediating mGluR-LTD through the regulation of mRNA translation complexes stalled at the level of elongation and/or termination.
    Title: UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.
  5. Stau2 stabilizes expression of Rgs4 mRNA via its 3' UTR in hippocampal neurons.
    Title: Staufen2 regulates neuronal target RNAs.
  6. Stau2 isoforms expressed in the developing eye of chicken embryo prevent microphthalmia.
    Title: The double-stranded RNA-binding protein Staufen 2 regulates eye size.
  7. Recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs.
    Title: Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
  8. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
    Title: Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
  9. These results represent an additional and important step in the characterization of Staufen2- mediated neuronal functions in rat brains.
    Title: Genome wide identification of Staufen2-bound mRNAs in embryonic rat brains.
  10. provide new tools to study and understand how Stau2-containing mRNPs are transported, translationally silenced during transport and/or locally expressed according to cell needs
    Title: Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93196

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular mRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
double-stranded RNA-binding protein Staufen homolog 2
Names
r-staufen protein
staufen, RNA binding protein, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007149.2 → NP_001007150.2  double-stranded RNA-binding protein Staufen homolog 2 isoform LL (A)

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q68SB1, Q68SB2, Q68SB3, Q68SB4, Q8R4C9, Q8R4D0
    UniProtKB/TrEMBL
    A6JFB1
    Conserved Domains (5) summary
    pfam16482
    Location:457 → 524
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:98 → 179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206 → 272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304 → 389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:3 → 70
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

  2. NM_001007150.2 → NP_001007151.1  double-stranded RNA-binding protein Staufen homolog 2 isoform SS

    See identical proteins and their annotated locations for NP_001007151.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JFB3
    Related
    ENSRNOP00000074008.2, ENSRNOT00000090346.3
    Conserved Domains (2) summary
    smart00358
    Location:276 → 342
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:425 → 480
    Staufen_C; Staufen C-terminal domain

  3. NM_001393676.1 → NP_001380605.1  double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000107014.1, ENSRNOT00000155543.1
    Conserved Domains (5) summary
    pfam16482
    Location:457 → 512
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:98 → 179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206 → 272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304 → 389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:3 → 70
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

  4. NM_134466.4 → NP_604461.2  double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)

    See identical proteins and their annotated locations for NP_604461.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q68SB1
    Conserved Domains (5) summary
    pfam16482
    Location:457 → 512
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:98 → 179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206 → 272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304 → 389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:3 → 70
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    7623528..7868206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287126.1 → XP_063143196.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

  2. XM_063287125.1 → XP_063143195.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

  3. XM_063287123.1 → XP_063143193.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X1

    Related
    ENSRNOP00000087673.2, ENSRNOT00000100311.2

  4. XM_063287127.1 → XP_063143197.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X4

  5. XM_063287128.1 → XP_063143198.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X5

  6. XM_063287124.1 → XP_063143194.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X2

    UniProtKB/Swiss-Prot
    Q68SB1, Q68SB2, Q68SB3, Q68SB4, Q8R4C9, Q8R4D0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68SB1.1 GenPept UniProtKB/Swiss-Prot:Q68SB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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