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Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171548, updated on 14-Nov-2024

Summary

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Official Symbol
Dkk3provided by RGD
Official Full Name
dickkopf WNT signaling pathway inhibitor 3provided by RGD
Primary source
RGD:621846
See related
EnsemblRapid:ENSRNOG00000016343 AllianceGenome:RGD:621846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p29; Reic
Summary
Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in several processes, including adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Predicted to be active in extracellular space. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 377.4), Brain (RPKM 198.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dkk3 in Genome Data Viewer
Location:
1q33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (175672834..175715867, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (166237969..166281271, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (176940424..176983076, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin specific peptidase 47 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2 Neighboring gene parvin, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation. Zhang LQ, et al. J Neuroinflammation, 2022 Jun 3. PMID 35658977, Free PMC Article
  2. Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells. Zhang X, et al. Mol Med Rep, 2017 Apr. PMID 28259940, Free PMC Article
  3. Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. Leonard DM, et al. J Biol Chem, 2000 Aug 18. PMID 10829019
  4. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats. Busceti CL, et al. Circ Res, 2023 May 26. PMID 37144413
  5. Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins. Montero-Pedrazuela A, et al. Endocrinology, 2003 Mar. PMID 12586781

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
    Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
  2. DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
    Title: DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
  3. DKK3 expression negatively regulates the osteogenic differentiation of dental follicle cells.
    Title: Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.
  4. WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3.
    Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.
  5. data do not support that thyroxine-binding protein p29 has a functional relationship with D2, but expression of p29 in the blood-CSF barrier suggests that it might be involved in T(4) transport to and from the CSF
    Title: Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adrenal gland development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dickkopf-related protein 3
Names
dickkopf 3 homolog
dickkopf homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138519.2 → NP_612528.2  dickkopf-related protein 3 precursor

    See identical proteins and their annotated locations for NP_612528.2

    Status: VALIDATED

    Source sequence(s)
    BC160821, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I857, B1H219, F7F7Y6
    Related
    ENSRNOP00000022301.5, ENSRNOT00000022301.8
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin; Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    175672834..175715867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230009.5 → XP_006230071.1  dickkopf-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006230071.1

    UniProtKB/TrEMBL
    A6I857, B1H219, F7F7Y6
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin; Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  2. XM_017588739.3 → XP_017444228.1  dickkopf-related protein 3 isoform X1

    UniProtKB/TrEMBL
    A6I857, B1H219, F7F7Y6
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin; Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
Nucleotide Protein Strain
Heading Accession and Version

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