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Stambp Stam binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 171565, updated on 17-Aug-2024

Summary

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Official Symbol
Stambpprovided by RGD
Official Full Name
Stam binding proteinprovided by RGD
Primary source
RGD:619963
See related
EnsemblRapid:ENSRNOG00000012227 AllianceGenome:RGD:619963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Amsh
Summary
Predicted to enable Lys63-specific deubiquitinase activity; protein domain specific binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of Ras protein signal transduction; negative regulation of phosphatidylinositol 3-kinase signaling; and protein K63-linked deubiquitination. Predicted to act upstream of or within mitotic cytokinesis; negative regulation of neuron apoptotic process; and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cleavage furrow and endosome. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 37.2), Kidney (RPKM 27.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117613730..117642163, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116055563..116083563, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115249343..115277340, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene deoxyguanosine kinase Neighboring gene uncharacterized LOC120102320 Neighboring gene actin gamma 2, smooth muscle Neighboring gene uncharacterized LOC120102321 Neighboring gene C-type lectin domain family 4, member F Neighboring gene CD207 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. McDonell LM, et al. Nat Genet, 2013 May. PMID 23542699, Free PMC Article
  2. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Suzuki S, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531206
  3. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Ishii N, et al. Mol Cell Biol, 2001 Dec. PMID 11713295, Free PMC Article
  4. Structural basis for autoinhibition of ESCRT-III CHMP3. Lata S, et al. J Mol Biol, 2008 May 9. PMID 18395747, Free PMC Article
  5. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. Itoh F, et al. EMBO J, 2001 Aug 1. PMID 11483516, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulatory role of alpha-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.
    Title: Modulatory role of α-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of hippocampal neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STAM-binding protein
Names
associated molecule with the SH3 domain of STAM
NP_612540.1
XP_006236788.1
XP_006236789.1
XP_038962914.1
XP_038962915.1
XP_063141530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138531.2 → NP_612540.1  STAM-binding protein

    See identical proteins and their annotated locations for NP_612540.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061711
    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
    Related
    ENSRNOP00000014708.3, ENSRNOT00000014708.7
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 115
    USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117613730..117642163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236726.5 → XP_006236788.1  STAM-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006236788.1

    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 115
    USP8_dimer; USP8 dimerization domain

  2. XM_039106986.2 → XP_038962914.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 115
    USP8_dimer; USP8 dimerization domain

  3. XM_039106987.2 → XP_038962915.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 115
    USP8_dimer; USP8 dimerization domain

  4. XM_006236727.5 → XP_006236789.1  STAM-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006236789.1

    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
    Conserved Domains (2) summary
    cd08066
    Location:254 → 424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:8 → 115
    USP8_dimer; USP8 dimerization domain

  5. XM_063285460.1 → XP_063141530.1  STAM-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q8R424
    UniProtKB/TrEMBL
    A6IAN4, A6IAN6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R424.1 GenPept UniProtKB/Swiss-Prot:Q8R424

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