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rcor-1 REST corepressor rcor-1 [ Caenorhabditis elegans ]

Gene ID: 171592, updated on 2-Nov-2024

Summary

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Official Symbol
rcor-1
Official Full Name
REST corepressor rcor-1
Primary source
WormBase:WBGene00022278
Locus tag
CELE_Y74C9A.4
See related
AllianceGenome:WB:WBGene00022278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rcor-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (17484..26781, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Alpha N-terminal protein methyltransferase 1 Neighboring gene Peptide P4 Neighboring gene pseudo Neighboring gene Sestrin homolog Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans. Kim HM, et al. Genetics, 2018 Jun. PMID 29588287, Free PMC Article
  2. H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans. Vandamme J, et al. Nucleic Acids Res, 2015 Nov 16. PMID 26476455, Free PMC Article
  3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
REST corepressor rcor-1
NP_001293207.1
  • Confirmed by transcript evidence
NP_001293208.1
  • Confirmed by transcript evidence
NP_490662.1
  • Partially confirmed by transcript evidence
NP_490663.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    17484..26781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058262.7 → NP_490663.1  REST corepressor rcor-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZI1
    Conserved Domains (2) summary
    pfam00249
    Location:499 → 538
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam00320
    Location:272 → 305
    GATA; GATA zinc finger

  2. NM_058261.5 → NP_490662.1  REST corepressor rcor-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490662.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KZI1, Q95Y41, V6CK76, V6CLK9
    Conserved Domains (2) summary
    pfam00249
    Location:502 → 541
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam00320
    Location:275 → 308
    GATA; GATA zinc finger

  3. NM_001306278.3 → NP_001293207.1  REST corepressor rcor-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK76
    Conserved Domains (2) summary
    pfam00249
    Location:471 → 510
    Myb_DNA-binding; Myb-like DNA-binding domain
    cl21498
    Location:164 → 208
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. NM_001306279.3 → NP_001293208.1  REST corepressor rcor-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLK9
    Conserved Domains (1) summary
    pfam00249
    Location:212 → 251
    Myb_DNA-binding; Myb-like DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95Y41.1

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