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Man2b2 mannosidase 2, alpha B2 [ Mus musculus (house mouse) ]

Gene ID: 17160, updated on 2-Nov-2024

Summary

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Official Symbol
Man2b2provided by MGI
Official Full Name
mannosidase 2, alpha B2provided by MGI
Primary source
MGI:MGI:1195262
See related
Ensembl:ENSMUSG00000029119 AllianceGenome:MGI:1195262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0935
Summary
Predicted to enable mannan endo-1,6-alpha-mannosidase activity. Involved in oligosaccharide catabolic process. Predicted to be located in extracellular region. Predicted to be active in lysosomal lumen. Is expressed in nervous system. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 75.3), ovary adult (RPKM 58.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Man2b2 in Genome Data Viewer
Location:
5 B3; 5 19.26 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36963913..36987973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36806813..36830649, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein P pseudogene Neighboring gene Morf4 family associated protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:37221807-37222107 Neighboring gene predicted gene, 52812 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Refinement of the expression pattern of a mouse homologue of the porcine 135-kDa alpha-d-mannosidase (MAN2B2). Tascou S, et al. Biochem Biophys Res Commun, 2000 Jun 16. PMID 10860856
  2. Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. Park C, et al. J Biol Chem, 2005 Nov 4. PMID 16115860, Free PMC Article
  3. Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Hiramoto S, et al. Biochem Biophys Res Commun, 1997 Dec 18. PMID 9425289
  4. Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells. Di Lorenzo G, et al. Mol Cell Proteomics, 2018 Aug. PMID 29773673, Free PMC Article
  5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables mannan endo-1,6-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epididymis-specific alpha-mannosidase
Names
135 kD alpha-D-mannosidase
135 kDa alpha-D-mannosidase
mannosidase alpha class 2B member 2
NP_001407765.1
NP_001407766.1
NP_032576.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420836.1 → NP_001407765.1  epididymis-specific alpha-mannosidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC169036
    Related
    ENSMUSP00000115495.2, ENSMUST00000124711.2

  2. NM_001420837.1 → NP_001407766.1  epididymis-specific alpha-mannosidase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC169036

  3. NM_008550.3 → NP_032576.2  epididymis-specific alpha-mannosidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032576.2

    Status: VALIDATED

    Source sequence(s)
    AC169036
    Consensus CDS
    CCDS19243.1
    UniProtKB/Swiss-Prot
    O54782, Q69ZV1, Q8BH85, Q9DBK2
    UniProtKB/TrEMBL
    Q3TND6
    Related
    ENSMUSP00000031002.4, ENSMUST00000031002.10
    Conserved Domains (3) summary
    cd10811
    Location:27 → 352
    GH38N_AMII_Epman_like; N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:358 → 439
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:491 → 1012
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    36963913..36987973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54782.2 GenPept UniProtKB/Swiss-Prot:O54782

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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