xpo-2 Exportin-2;Exportin-2 C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: xpo-2
Gene description: Exportin-2;Exportin-2 C-terminal domain-containing protein
Locus tag: CELE_Y48G1A.5
See related: AllianceGenome:WB:WBGene00002079
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See xpo-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (318549..323352, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48G1A_54.b (e-PCR)
- UniSTS:322970

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Exportin-2;Exportin-2 C-terminal domain-containing protein

NP_001293261.1

Confirmed by transcript evidence

NP_490716.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

318549..323352 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058315.7 → NP_490716.1 Exportin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490716.1

Status: REVIEWED

UniProtKB/TrEMBL

Q965V4

Conserved Domains (2) summary

COG5657
Location:3 → 799

CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]

pfam08506
Location:150 → 513

Cse1
NM_001306332.3 → NP_001293261.1 Exportin-2 C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293261.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CKP0

Conserved Domains (1) summary

pfam03378
Location:4 → 89

CAS_CSE1; CAS/CSE protein, C-terminus