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daf-25 Dauer abnormal formation protein 25 [ Caenorhabditis elegans ]

Gene ID: 171623, updated on 2-Nov-2024

Summary

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Official Symbol
daf-25
Official Full Name
Dauer abnormal formation protein 25
Primary source
WormBase:WBGene00000917
Locus tag
CELE_Y48G1A.3
See related
AllianceGenome:WB:WBGene00000917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in several processes, including dauer exit; positive regulation of cGMP-mediated signaling; and protein localization to cell periphery. Located in non-motile cilium. Is expressed in intestine and sensory neurons. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-25 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (332604..337845)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Exportin-2;Exportin-2 C-terminal domain-containing protein Neighboring gene Nucleolar protein 14 Neighboring gene Malignant brain tumor repeat protein 1 Neighboring gene Transposase Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling. Lenuzzi M, et al. J Exp Zool B Mol Dev Evol, 2023 Mar. PMID 34379868
  2. A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. Fujiwara M, et al. PLoS Genet, 2010 Nov 24. PMID 21124861, Free PMC Article
  3. Distinct functional constraints partition sequence conservation in a cis-regulatory element. Barrière A, et al. PLoS Genet, 2011 Jun. PMID 21655084, Free PMC Article
  4. Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport. van der Burght SN, et al. Curr Biol, 2020 Nov 2. PMID 32916106
  5. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. Jensen VL, et al. PLoS Genet, 2010 Nov 24. PMID 21124868, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer exit IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to microvillus membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to non-motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor localization to non-motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dauer abnormal formation protein 25
NP_490719.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    332604..337845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058318.5 → NP_490719.1  Dauer abnormal formation protein 25 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N3Q8
    Conserved Domains (4) summary
    cd00204
    Location:9 → 127
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01753
    Location:321 → 357
    zf-MYND; MYND finger
    pfam12796
    Location:12 → 105
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:10 → 38
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N3Q8.2

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