U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mbtr-1 Malignant brain tumor repeat protein 1 [ Caenorhabditis elegans ]

Gene ID: 171624, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mbtr-1
Official Full Name
Malignant brain tumor repeat protein 1
Primary source
WormBase:WBGene00021661
Locus tag
CELE_Y48G1A.6
See related
AllianceGenome:WB:WBGene00021661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mbtr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (343069..348424, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleolar protein 14 Neighboring gene Dauer abnormal formation protein 25 Neighboring gene Transposase Neighboring gene BTB domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development. Koester-Eiserfunke N, et al. PLoS Genet, 2011 Mar. PMID 21437264, Free PMC Article
  2. LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Harrison MM, et al. Genetics, 2007 May. PMID 17409073, Free PMC Article
  3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Malignant brain tumor repeat protein 1
NP_001122542.1
  • Confirmed by transcript evidence
NP_001122543.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    343069..348424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129070.2 → NP_001122542.1  Malignant brain tumor repeat protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122542.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0SQM0, A9D1A1
    Conserved Domains (3) summary
    smart00561
    Location:217 → 326
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:374 → 439
    MBT; mbt repeat
    cl17705
    Location:75 → 164
    MBT; mbt repeat

  2. NM_001129071.3 → NP_001122543.1  Malignant brain tumor repeat protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0SQM0
    Conserved Domains (3) summary
    smart00561
    Location:204 → 313
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    cd20099
    Location:356 → 447
    MBT_dSfmbt-like_rpt3; third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family
    cl45897
    Location:466 → 536
    MBT; malignant brain tumor (MBT) repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0SQM0.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools