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tol-1 TIR domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171635, updated on 2-Nov-2024

Summary

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Official Symbol
tol-1
Official Full Name
TIR domain-containing protein
Primary source
WormBase:WBGene00006593
Locus tag
CELE_C07F11.1
See related
AllianceGenome:WB:WBGene00006593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling receptor activity. Involved in defense response to Gram-negative bacterium and embryo development. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in neurons. Orthologous to several human genes including TRIL (TLR4 interactor with leucine rich repeats); CHAD (chondroadherin); and CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tol-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (444003..461605)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene GTP-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. Rangan KJ, et al. Science, 2016 Sep 23. PMID 27708039, Free PMC Article
  2. Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior. Brandt JP, et al. Curr Biol, 2015 Aug 31. PMID 26279230, Free PMC Article
  3. Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria. Portal-Celhay C, et al. FASEB J, 2013 Feb. PMID 23085995, Free PMC Article
  4. A transcriptomic insight into the infective juvenile stage of the insect parasitic nematode, Heterorhabditis indica. Somvanshi VS, et al. BMC Genomics, 2016 Mar 1. PMID 26931371, Free PMC Article
  5. Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans. Kim D. Dis Model Mech, 2008 Nov-Dec. PMID 19093025, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that pathologies in tol-1(-) mutant nematodes are indistinguishable from wild type animals, indicating that nematodes do not employ this orthologue for detection of Coxiella burnetii
    Title: Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii.
  2. For pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. TOL-1 acts together with many conserved components of TLR signaling.
    Title: Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.
  3. The results indicate that TOL-1 has a direct role in defence response to certain Gram-negative bacteria and indicate that part of the TLR-mediated immunity might be evolutionarily conserved.
    Title: A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TIR domain-containing protein
NP_001020983.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    444003..461605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025812.6 → NP_001020983.1  TIR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001020983.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIW9, Q9N5Z3
    Conserved Domains (6) summary
    COG4886
    Location:265 → 600
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:786 → 809
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307 → 331
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:785 → 844
    LRR_8; Leucine rich repeat
    pfam14580
    Location:806 → 890
    LRR_9; Leucine-rich repeat
    cl23749
    Location:1056 → 1194
    TIR_2; TIR domain
Nucleotide Protein
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