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psf-3 DNA replication complex GINS protein PSF3 [ Caenorhabditis elegans ]

Gene ID: 171645, updated on 2-Nov-2024

Summary

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Official Symbol
psf-3
Official Full Name
DNA replication complex GINS protein PSF3
Primary source
WormBase:WBGene00022043
Locus tag
CELE_Y65B4BR.8
See related
AllianceGenome:WB:WBGene00022043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of GINS complex. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See psf-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (534455..535344)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene Nascent polypeptide-associated complex subunit alpha Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. Ossareh-Nazari B, et al. G3 (Bethesda), 2016 Oct 13. PMID 27543292, Free PMC Article
  2. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo. Benkemoun L, et al. J Cell Biol, 2014 May 26. PMID 24841566, Free PMC Article
  3. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article
  4. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
  5. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication complex GINS protein PSF3
NP_490748.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    534455..535344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058347.7 → NP_490748.1  DNA replication complex GINS protein PSF3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL54
    Conserved Domains (1) summary
    cd11713
    Location:72 → 179
    GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
Nucleotide Protein
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