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wwp-1 E3 ubiquitin-protein ligase wwp-1 [ Caenorhabditis elegans ]

Gene ID: 171647, updated on 2-Nov-2024

Summary

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Official Symbol
wwp-1
Official Full Name
E3 ubiquitin-protein ligase wwp-1
Primary source
WormBase:WBGene00007009
Locus tag
CELE_Y65B4BR.4
See related
AllianceGenome:WB:WBGene00007009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Is expressed in several structures, including coelomocyte; intestine; nervous system; rectum; and vulval muscle. Orthologous to several human genes including WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wwp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (537122..542204)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nascent polypeptide-associated complex subunit alpha Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation. Peters TW, et al. G3 (Bethesda), 2018 Nov 6. PMID 30194090, Free PMC Article
  2. A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Carrano AC, et al. Nat Commun, 2014 May 8. PMID 24805825, Free PMC Article
  3. Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study. Saul N, et al. Biogerontology, 2022 Aug. PMID 35748965, Free PMC Article
  4. Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression. Cai H, et al. Int J Mol Sci, 2022 Sep 29. PMID 36232823, Free PMC Article
  5. Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. Courbard JR, et al. J Biol Chem, 2002 Nov 22. PMID 12226085

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WWP-1 directly interacts with KLF-1 and mediates multiple monoubiquitylation of KLF-1 in vitro and in cellulo. The data support a model in which modulation of KLF-1 by WWP-1 regulates diet-restriction-induced longevity.
    Title: A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
  2. WWP-1 and DAF-16 function in parallel within the fundamental DAF-2 insulin/IGF-1 signaling network to regulate fundamental cellular responses in C. elegans
    Title: WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
  3. results indicate that WWP-1 and UBC-18 function to ubiquitinate substrates that regulate diet-restriction-induced longevity
    Title: A conserved ubiquitination pathway determines longevity in response to diet restriction.
  4. WWP-1 is the putative E3 ubiquitin ligase mediating the degradation of the large RNA polymerase II (RNA pol II) subunit, AMA-1 under UV irradiation.
    Title: Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity, acting on a protein IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase wwp-1
NP_001293271.1
  • Confirmed by transcript evidence
NP_001293272.1
  • Confirmed by transcript evidence
NP_740775.1
  • Confirmed by transcript evidence
NP_740776.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    537122..542204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170794.7 → NP_740775.1  E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XU3, Q9N2Z7, V6CJJ8, V6CLY4
    Conserved Domains (3) summary
    COG5021
    Location:251 → 794
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:221 → 250
    WW; WW domain
    cl14603
    Location:29 → 147
    C2; C2 domain

  2. NM_171831.4 → NP_740776.1  E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XU3
    Conserved Domains (5) summary
    smart00456
    Location:325 → 357
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:461 → 789
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:438 → 790
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:255 → 284
    WW; WW domain
    cl14603
    Location:29 → 147
    C2; C2 domain

  3. NM_001306342.3 → NP_001293271.1  E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLY4
    Conserved Domains (1) summary
    COG5021
    Location:39 → 507
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  4. NM_001306343.3 → NP_001293272.1  E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293272.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJJ8
    Conserved Domains (1) summary
    COG5021
    Location:39 → 505
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N2Z7.2

Gene LinkOut

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