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vps-20 Charged multivesicular body protein 6 [ Caenorhabditis elegans ]

Gene ID: 171654, updated on 2-Nov-2024

Summary

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Official Symbol
vps-20
Official Full Name
Charged multivesicular body protein 6
Primary source
WormBase:WBGene00022027
Locus tag
CELE_Y65B4A.3
See related
AllianceGenome:WB:WBGene00022027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-20 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (636804..637852)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA helicase Neighboring gene ncRNA Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene Cytidyltransferase-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Block S, et al. Methods Mol Biol, 2019. PMID 31250303, Free PMC Article
  2. Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments. Fyfe I, et al. J Biol Chem, 2011 Sep 30. PMID 21835927, Free PMC Article
  3. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. Schuh AL, et al. Biochem J, 2015 Mar 15. PMID 25588614, Free PMC Article
  4. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
  5. Differential physiological roles of ESCRT complexes in Caenorhabditis elegans. Kim DW, et al. Mol Cells, 2011 Jun. PMID 21688204, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Charged multivesicular body protein 6
NP_490762.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    636804..637852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058361.7 → NP_490762.1  Charged multivesicular body protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490762.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL60
    Conserved Domains (1) summary
    pfam03357
    Location:23 → 184
    Snf7; Snf7
Nucleotide Protein
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