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hasp-2 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

Gene ID: 171659, updated on 2-Nov-2024

Summary

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Official Symbol
hasp-2
Official Full Name
non-specific serine/threonine protein kinase
Primary source
WormBase:WBGene00021214
Locus tag
CELE_Y18H1A.10
See related
AllianceGenome:WB:WBGene00021214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3T3 kinase activity. Predicted to be involved in intracellular signal transduction and mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hasp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (683724..686599, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene choline-phosphate cytidylyltransferase Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Histidine phosphatase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of Caenorhabditis elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline. Macaraeg J, et al. Biol Open, 2022 Jul 15. PMID 35678140, Free PMC Article
  2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-specific serine/threonine protein kinase
NP_490768.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    683724..686599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058367.5 → NP_490768.3  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490768.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL96
    Conserved Domains (1) summary
    pfam12330
    Location:75 → 377
    Haspin_kinase; Haspin like kinase domain
Nucleotide Protein
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