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hgap-1 Rap-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171663, updated on 2-Nov-2024

Summary

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Official Symbol
hgap-1
Official Full Name
Rap-GAP domain-containing protein
Primary source
WormBase:WBGene00021209
Locus tag
CELE_Y18H1A.3
See related
AllianceGenome:WB:WBGene00021209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1) and RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hgap-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (700278..715875, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histidine phosphatase family protein Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein;Cir_N domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ATP-dependent DNA helicase;ATP-dependent DNA helicase PIF1 Neighboring gene RGS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
  2. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Martin TD, et al. Mol Cell, 2014 Jan 23. PMID 24389102, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rap-GAP domain-containing protein
NP_001293169.1
  • Confirmed by transcript evidence
NP_001293170.1
  • Confirmed by transcript evidence
NP_001293171.1
  • Confirmed by transcript evidence
NP_001367998.1
  • Confirmed by transcript evidence
NP_001368371.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    700278..715875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380470.3 → NP_001367998.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL92
    Conserved Domains (1) summary
    pfam02145
    Location:993 → 1148
    Rap_GAP; Rap/ran-GAP

  2. NM_001380463.2 → NP_001368371.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLC2
    Conserved Domains (1) summary
    pfam02145
    Location:1111 → 1266
    Rap_GAP; Rap/ran-GAP

  3. NM_001306242.3 → NP_001293171.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293171.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLD4
    Conserved Domains (1) summary
    pfam02145
    Location:772 → 927
    Rap_GAP; Rap/ran-GAP

  4. NM_001306241.3 → NP_001293170.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJZ0
    Conserved Domains (1) summary
    pfam02145
    Location:553 → 708
    Rap_GAP; Rap/ran-GAP

  5. NM_001306240.3 → NP_001293169.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIT8
    Conserved Domains (1) summary
    pfam02145
    Location:414 → 569
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein
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