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T06A4.3 Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171668, updated on 2-Nov-2024

Summary

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Official Symbol
T06A4.3
Official Full Name
Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein
Primary source
WormBase:WBGene00020283
Locus tag
CELE_T06A4.3
See related
AllianceGenome:WB:WBGene00020283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T06A4.3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (763478..770720)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Apyrase;TransThyretin-Related family domain Neighboring gene MiRP K channel accessory Subunit Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein
NP_001021611.1
  • Confirmed by transcript evidence
NP_001021612.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    763478..770720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026440.5 → NP_001021611.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6A577
    Conserved Domains (3) summary
    cd03860
    Location:128 → 438
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:468 → 505
    ShK; ShK domain-like
    pfam02244
    Location:31 → 98
    Propep_M14; Carboxypeptidase activation peptide

  2. NM_001026441.4 → NP_001021612.1  Peptidase M14 carboxypeptidase A domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6A576
    Conserved Domains (2) summary
    cd03860
    Location:128 → 438
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:31 → 98
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein
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