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zfh-2 Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein [ Caenorhabditis elegans ]

Gene ID: 171670, updated on 2-Nov-2024

Summary

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Official Symbol
zfh-2
Official Full Name
Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein
Primary source
WormBase:WBGene00022518
Locus tag
CELE_ZC123.3
See related
AllianceGenome:WB:WBGene00022518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in body wall musculature; enteric muscle; nerve ring; neurons; and vulval muscle. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zfh-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
18
Sequence:
Chromosome: I; NC_003279.8 (803368..834765)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A microcosm of the biomedical research experience for upper-level undergraduates. Hurd DD. CBE Life Sci Educ, 2008 Summer. PMID 18519612, Free PMC Article
  2. Genes in human obesity loci are causal obesity genes in C. elegans. Ke W, et al. PLoS Genet, 2021 Sep. PMID 34492009, Free PMC Article
  3. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article
  4. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
  5. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein
NP_001368413.1
  • Confirmed by transcript evidence
NP_001368414.1
  • Confirmed by transcript evidence
NP_001368415.1
  • Product from WormBase gene class zfh;
    Confirmed by transcript evidence
NP_001368416.1
  • Product from WormBase gene class zfh;
    Confirmed by transcript evidence
NP_001368417.1
  • Confirmed by transcript evidence
NP_001370923.1
  • Product from WormBase gene class zfh;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    803368..834765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383286.2 → NP_001370923.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLN5
    Conserved Domains (5) summary
    smart00389
    Location:856 → 915
    HOX; Homeodomain
    COG5576
    Location:979 → 1091
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:502 → 525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:1035 → 1087
    Homeobox; Homeobox domain

  2. NM_001380621.1 → NP_001368413.1  Zinc finger protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJA9
    Conserved Domains (5) summary
    smart00389
    Location:494 → 553
    HOX; Homeodomain
    COG5576
    Location:617 → 729
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:112 → 132
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:140 → 163
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:673 → 725
    Homeobox; Homeobox domain

  3. NM_001380622.1 → NP_001368414.1  Zinc finger protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CKG1
    Conserved Domains (5) summary
    smart00389
    Location:476 → 535
    HOX; Homeodomain
    COG5576
    Location:599 → 711
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:94 → 114
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:122 → 145
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:655 → 707
    Homeobox; Homeobox domain

  4. NM_001380626.1 → NP_001368415.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLT5
    Conserved Domains (6) summary
    smart00389
    Location:378 → 437
    HOX; Homeodomain
    smart00451
    Location:48 → 77
    ZnF_U1; U1-like zinc finger
    COG5576
    Location:501 → 613
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:98 → 120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24 → 47
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:557 → 609
    Homeobox; Homeobox domain

  5. NM_001380629.1 → NP_001368416.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLS4
    Conserved Domains (4) summary
    smart00389
    Location:264 → 323
    HOX; Homeodomain
    COG5576
    Location:387 → 499
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00020
    Location:819 → 841
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:443 → 495
    Homeobox; Homeobox domain

  6. NM_001380630.1 → NP_001368417.1  Zinc finger homeobox protein 4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLP1
    Conserved Domains (3) summary
    COG5576
    Location:92 → 204
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00020
    Location:524 → 546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:148 → 200
    Homeobox; Homeobox domain
Nucleotide Protein
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