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gsa-1 Guanine nucleotide-binding protein G(s) subunit alpha [ Caenorhabditis elegans ]

Gene ID: 171687, updated on 2-Nov-2024

Summary

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Official Symbol
gsa-1
Official Full Name
Guanine nucleotide-binding protein G(s) subunit alpha
Primary source
WormBase:WBGene00001745
Locus tag
CELE_R06A10.2
See related
AllianceGenome:WB:WBGene00001745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; nematode pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; dystonia 25; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to several human genes including GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gsa-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (1068484..1074343)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Glutaredoxin-1 Neighboring gene Conserved plasma membrane protein;Low-density lipoprotein receptor domain class A;Transmembrane protein Neighboring gene vesicle-fusing ATPase Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Autophagy-related protein 9;RGS domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and expression of the gsa-1 gene encoding a G protein alpha(s) subunit in C. elegans. Park JH, et al. Gene, 1997 Jul 31. PMID 9272860
  2. Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. Cao P, et al. FASEB J, 2012 Feb. PMID 22090313, Free PMC Article
  3. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cunningham KA, et al. Cell Metab, 2012 Jul 3. PMID 22768843, Free PMC Article
  4. Locomotion Behavior Is Affected by the Gα(S) Pathway and the Two-Pore-Domain K(+) Channel TWK-7 Interacting in GABAergic Motor Neurons in Caenorhabditis elegans. Gottschling DC, et al. Genetics, 2017 May. PMID 28341653, Free PMC Article
  5. The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans. Liu F, et al. Sci Rep, 2017 Apr 4. PMID 28377576, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galpha/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
    Title: Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase C signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of chemical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Guanine nucleotide-binding protein G(s) subunit alpha
NP_001367988.1
  • Confirmed by transcript evidence
NP_001368357.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1068484..1074343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380927.2 → NP_001367988.1  Guanine nucleotide-binding protein G(s) subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF72, Q7KPV0
    Conserved Domains (1) summary
    cd00066
    Location:40 → 372
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  2. NM_001380932.1 → NP_001368357.1  Guanine nucleotide-binding protein G(s) subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CL61
    Conserved Domains (1) summary
    cd00066
    Location:7 → 279
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein
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