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Mas1 MAS1 oncogene [ Mus musculus (house mouse) ]

Gene ID: 17171, updated on 2-Nov-2024

Summary

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Official Symbol
Mas1provided by MGI
Official Full Name
MAS1 oncogeneprovided by MGI
Primary source
MGI:MGI:96918
See related
Ensembl:ENSMUSG00000068037 AllianceGenome:MGI:96918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MasR; Mgra; Mas-1
Summary
Enables angiotensin receptor activity and peptide binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and regulation of inflammatory response. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; extraembryonic component; gut; reproductive system; and spleen. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 8.4), cortex adult (RPKM 2.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Mas1 in Genome Data Viewer
Location:
17 A1; 17 8.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13056981..13087037, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12838841..12868150, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene antisense Igf2r RNA Neighboring gene STARR-seq mESC enhancer starr_41859 Neighboring gene RAN GTPase activating protein 1 pseudogene Neighboring gene RAN GTPase activating protein 1 pseudogene Neighboring gene ribosomal protein L41 pseudogene Neighboring gene predicted gene, 53988 Neighboring gene MAS-related GPR, member H Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Receptor MAS protects mice against hypothermia and mortality induced by endotoxemia. Souza LL, et al. Shock, 2014 Apr. PMID 24430551
  2. Interaction between Mas and the angiotensin AT1 receptor in the amygdala. Von Bohlen und Halbach O, et al. J Neurophysiol, 2000 Apr. PMID 10758111
  3. Imprinting of the murine MAS protooncogene is restricted to its antisense RNA. Alenina N, et al. Biochem Biophys Res Commun, 2002 Jan 25. PMID 11798184
  4. Increased vascular sympathetic modulation in mice with Mas receptor deficiency. Rabello Casali K, et al. J Renin Angiotensin Aldosterone Syst, 2016 Apr-Jun. PMID 27080540, Free PMC Article
  5. Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. Morales MG, et al. Dis Model Mech, 2016 Apr. PMID 26851244, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
    Title: ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
  2. Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
    Title: Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
  3. Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
    Title: Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
  4. Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
    Title: Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
  5. Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
    Title: Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
  6. Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle.
    Title: Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle.
  7. Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
    Title: Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
  8. study demonstrates that the activation of MAS is important for microglia recruitment and vascular growth in the developing retina.
    Title: The role of receptor MAS in microglia-driven retinal vascular development.
  9. MasR deficiency did not influence body weight, systolic blood pressure at baseline and during AngII infusion, or serum cholesterol concentrations in either Apoe-/- or Ldlr-/- mice. MasR deficiency increased AngII-induced atherosclerosis in aortic arches of Ldlr-/- mice associated with increased oxidative stress and apoptosis in aortic root sections.
    Title: Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
  10. Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor.
    Title: Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables angiotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables angiotensin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to gonadotropin IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proto-oncogene Mas
Names
MAS proto-oncogene
Mas receptor
Mas-related G protein-coupled receptor a
angiotensin-(1-7) receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008552.5 → NP_032578.2  proto-oncogene Mas

    See identical proteins and their annotated locations for NP_032578.2

    Status: VALIDATED

    Source sequence(s)
    AK030265, AL589878
    Consensus CDS
    CCDS28394.1
    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Related
    ENSMUSP00000086409.4, ENSMUST00000089015.10
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13056981..13087037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523296.5 → XP_006523359.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_006523359.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011246193.3 → XP_011244495.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_011244495.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006523294.4 → XP_006523357.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_006523357.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_011246192.3 → XP_011244494.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_011244494.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_011246191.3 → XP_011244493.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_011244493.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_011246190.3 → XP_011244492.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_011244492.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Related
    ENSMUSP00000125108.2, ENSMUST00000162333.8
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_030249523.2 → XP_030105383.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Related
    ENSMUSP00000132300.2, ENSMUST00000165020.8
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  8. XM_030249524.2 → XP_030105384.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  9. XM_006523293.5 → XP_006523356.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_006523356.1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  10. XM_017317270.2 → XP_017172759.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    O35944, P30554, Q8BHI8
    UniProtKB/TrEMBL
    Q0VB49, Q9D5Q2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30554.2 GenPept UniProtKB/Swiss-Prot:P30554

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