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tln-1 FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171736, updated on 2-Nov-2024

Summary

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Official Symbol
tln-1
Official Full Name
FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein
Primary source
WormBase:WBGene00006771
Locus tag
CELE_Y71G12B.11
See related
AllianceGenome:WB:WBGene00006771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable integrin binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; regulation of vulval development; and vulval cell fate specification. Located in basement membrane; contractile muscle fiber; and lateral plasma membrane. Is expressed in several structures, including Psub3; Psub4; Z2; Z3; and distal tip cell. Orthologous to several human genes including TLN2 (talin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tln-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (1721590..1740692)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Autophagy-related protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha Neighboring gene hydroxymethylglutaryl-CoA lyase Neighboring gene ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An integrin binding motif in TLN-1/talin plays a minor role in motility and ovulation. Sadeghian F, et al. MicroPubl Biol, 2023. PMID 36685729, Free PMC Article
  2. Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans. Moulder GL, et al. Mol Biol Cell, 1996 Aug. PMID 8856663, Free PMC Article
  3. Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans. Rose AM, et al. Mol Gen Genet, 1984. PMID 6593563
  4. Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. Sakai Y, et al. PLoS Genet, 2023 Dec. PMID 38150455, Free PMC Article
  5. The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN. Qiu Z, et al. Biochem Biophys Res Commun, 2022 Jan 1. PMID 34844120

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
    Title: The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein
NP_001249039.1
  • Confirmed by transcript evidence
NP_001300474.1
  • Confirmed by transcript evidence
NP_001300476.1
  • Confirmed by transcript evidence
NP_001359949.1
  • Confirmed by transcript evidence
NP_001368504.1
  • Confirmed by transcript evidence
NP_001380167.1
  • Confirmed by transcript evidence
NP_490886.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1721590..1740692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373653.2 → NP_001359949.1  FERM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XN3
    Conserved Domains (5) summary
    smart00295
    Location:89 → 341
    B41; Band 4.1 homologues
    cd10569
    Location:337 → 428
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam09141
    Location:525 → 683
    Talin_middle; Talin, middle domain
    pfam16511
    Location:4 → 84
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:675 → 778
    I_LWEQ; I/LWEQ domain

  2. NM_058485.8 → NP_490886.2  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490886.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGK1
    Conserved Domains (10) summary
    cd12150
    Location:1667 → 1839
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:89 → 341
    B41; Band 4.1 homologues
    smart00307
    Location:2357 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:337 → 428
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:232 → 341
    FERM_M; FERM central domain
    pfam08913
    Location:1863 → 1984
    VBS; Vinculin Binding Site
    pfam09141
    Location:525 → 683
    Talin_middle; Talin, middle domain
    pfam09379
    Location:91 → 135
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 84
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:698 → 783
    I_LWEQ; I/LWEQ domain

  3. NM_001313545.3 → NP_001300474.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATT6
    Conserved Domains (6) summary
    cd12150
    Location:1302 → 1474
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:1992 → 2184
    ILWEQ; I/LWEQ domain
    cd10569
    Location:1 → 63
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1498 → 1619
    VBS; Vinculin Binding Site
    pfam09141
    Location:160 → 318
    Talin_middle; Talin, middle domain
    cl19756
    Location:333 → 428
    I_LWEQ; I/LWEQ domain

  4. NM_001381251.1 → NP_001368504.1  Talin central domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQU9
    Conserved Domains (3) summary
    cd10569
    Location:1 → 63
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam09141
    Location:160 → 318
    Talin_middle; Talin, middle domain
    cl19756
    Location:310 → 388
    I_LWEQ; I/LWEQ domain

  5. NM_001262110.3 → NP_001249039.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4S9F5
    Conserved Domains (4) summary
    cd12150
    Location:1004 → 1176
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:1694 → 1886
    ILWEQ; I/LWEQ domain
    TIGR02168
    Location:189 → 440
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam08913
    Location:1200 → 1321
    VBS; Vinculin Binding Site

  6. NM_001392973.1 → NP_001380167.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBK6
    Conserved Domains (3) summary
    cd12150
    Location:625 → 797
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:1315 → 1507
    ILWEQ; I/LWEQ domain
    pfam08913
    Location:821 → 942
    VBS; Vinculin Binding Site

  7. NM_001313547.3 → NP_001300476.1  I/LWEQ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUD9
    Conserved Domains (1) summary
    cl19756
    Location:5 → 54
    I_LWEQ; I/LWEQ domain
Nucleotide Protein
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