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emr-1 Emerin homolog 1 [ Caenorhabditis elegans ]

Gene ID: 171752, updated on 2-Nov-2024

Summary

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Official Symbol
emr-1
Official Full Name
Emerin homolog 1
Primary source
WormBase:WBGene00001309
Locus tag
CELE_M01D7.6
See related
AllianceGenome:WB:WBGene00001309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables lamin binding activity. Involved in several processes, including mitotic cytokinesis; nuclear envelope organization; and response to X-ray. Located in nuclear inner membrane. Is expressed in body wall musculature; intestine; nervous system; and pharynx. Used to study Emery-Dreifuss muscular dystrophy. Orthologous to human LEMD1 (LEM domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See emr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (1842445..1843227)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein subunit alpha Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene GHMP kinase C-terminal domain-containing protein;Galactokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis. Barkan R, et al. Mol Biol Cell, 2012 Feb. PMID 22171324, Free PMC Article
  2. The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. Gruenbaum Y, et al. J Cell Sci, 2002 Mar 1. PMID 11870211
  3. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. Cohen M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490171
  4. Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans. Morales-Martínez A, et al. J Cell Sci, 2015 Mar 15. PMID 25653391
  5. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Wiesel N, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162544, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate a specific role of EMR-1 in neuromuscular junction activity that may contribute to Emery-Dreifuss muscular dystrophy in humans
    Title: Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.
  2. these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle.
    Title: Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
  3. LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy
    Title: MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lamin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emerin homolog 1
NP_490907.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1842445..1843227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058506.6 → NP_490907.1  Emerin homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01971
    Conserved Domains (1) summary
    pfam03020
    Location:2 → 40
    LEM; LEM domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01971.1

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