arl-13 ADP-ribosylation factor-like protein 13B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arl-13
Official Full Name: ADP-ribosylation factor-like protein 13B
Primary source: WormBase:WBGene00021349
Locus tag: CELE_Y37E3.5
See related: AllianceGenome:WB:WBGene00021349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in cilium organization; receptor localization to non-motile cilium; and sensory perception of chemical stimulus. Acts upstream of or within motile cilium assembly. Located in several cellular components, including cell projection membrane; ciliary inversin compartment; and leading edge of dendritic growth cone. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to several human genes including ARL13B (ADP ribosylation factor like GTPase 13B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See arl-13 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (2065692..2069098)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate that ARL-3 is a unique small GTPase with unusual high intrinsic GDP release but low intrinsic GTP binding rate. Importantly, ARL-13 acts as a nucleotide exchange factor (GEF) of ARL-3, while UNC-119 can stabilize the GTP binding of ARL-3. We further show that excess inactivated ARL-3 compromises ciliogenesis.
Title: GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
The ciliary targeting and restricted localization of NPHP-2, ARL-13, and UNC-119 does not require TZ-, doublet region, and InvC-associated genes in C. elegans.
Title: The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans.
data reveal a novel but conserved role for the SUMOylation modification of ciliary small GTPase ARL13B in specifically regulating the proper ciliary targeting of various sensory receptors
Title: SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
Data suggest that two conserved small GTPases, ARL-13 and ARL-3, coordinate to regulate intraflagellar transport and that perturbing this balance results in cilia deformation.
Title: The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.
arl-13 interacts genetically with other ciliogenic and ciliary transport-associated genes in maintaining cilium structure/morphology and anterograde IFT stability
Title: Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor localization to non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary inversin compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in leading edge of dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 13B

NP_001032986.1

Confirmed by transcript evidence

NP_001032987.1

Confirmed by transcript evidence

NP_001360352.1

Confirmed by transcript evidence

NP_001380169.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2065692..2069098

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001037898.3 → NP_001032987.1 ADP-ribosylation factor-like protein 13B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001032987.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0N8

Conserved Domains (2) summary

COG1100
Location:23 → 166

Gem1; GTPase SAR1 family domain [General function prediction only]

cl21455
Location:27 → 137

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001373681.2 → NP_001360352.1 ADP-ribosylation factor-like protein 13B [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

X5M8W6
NM_001037897.3 → NP_001032986.1 ADP-ribosylation factor-like protein 13B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001032986.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0N8, Q2V075

Conserved Domains (2) summary

COG1100
Location:23 → 166

Gem1; GTPase SAR1 family domain [General function prediction only]

cl21455
Location:27 → 137

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001393008.1 → NP_001380169.1 ADP-ribosylation factor-like protein 13B [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

X5M5S1