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abt-2 ABC transporter domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171782, updated on 2-Nov-2024

Summary

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Official Symbol
abt-2
Official Full Name
ABC transporter domain-containing protein
Primary source
WormBase:WBGene00000020
Locus tag
CELE_F12B6.1
See related
AllianceGenome:WB:WBGene00000020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); autosomal recessive congenital ichthyosis (multiple); hypolipoproteinemia (multiple); retinal degeneration (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abt-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
33
Sequence:
Chromosome: I; NC_003279.8 (2255921..2272866, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ligand-Gated ion Channel Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Tropomyosin;Tubulin-specific chaperone A Neighboring gene Cyclin-dependent kinase 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
  2. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
  3. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ABC transporter domain-containing protein
NP_001368466.1
  • Confirmed by transcript evidence
NP_490949.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2255921..2272866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058548.7 → NP_490949.3  ABC transporter domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490949.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SD95, Q1RS86
    Conserved Domains (2) summary
    TIGR01257
    Location:39 → 2117
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:929 → 1134
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

  2. NM_001381367.1 → NP_001368466.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LXB2
    Conserved Domains (1) summary
    TIGR01257
    Location:2 → 2080
    rim_protein; retinal-specific rim ABC transporter
Nucleotide Protein
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