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icp-1 Inner centromere protein ARK-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171788, updated on 2-Nov-2024

Summary

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Official Symbol
icp-1
Official Full Name
Inner centromere protein ARK-binding domain-containing protein
Primary source
WormBase:WBGene00002047
Locus tag
CELE_Y39G10AR.13
See related
AllianceGenome:WB:WBGene00002047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein serine/threonine kinase activator activity. Involved in mitotic cytokinesis and nuclear division. Located in kinetochore and nucleus. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See icp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (2304513..2306790, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene TPX2 domain-containing protein Neighboring gene Ectopic P granules protein 2 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene 5-methylcytosine rRNA methyltransferase nsun-4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Davies T, et al. Dev Cell, 2014 Jul 28. PMID 25073157, Free PMC Article
  2. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. Bishop JD, et al. J Biol Chem, 2002 Aug 2. PMID 12048181, Free PMC Article
  3. Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo. Riefler GM, et al. J Biol Chem, 2008 May 9. PMID 18334486, Free PMC Article
  4. Functional analysis of kinetochore assembly in Caenorhabditis elegans. Oegema K, et al. J Cell Biol, 2001 Jun 11. PMID 11402065, Free PMC Article
  5. CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. Romano A, et al. J Cell Biol, 2003 Apr 28. PMID 12707312, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome movement towards spindle pole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Inner centromere protein ARK-binding domain-containing protein
NP_001293363.1
  • Confirmed by transcript evidence
NP_490956.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2304513..2306790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058555.9 → NP_490956.1  Inner centromere protein ARK-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE37
    Conserved Domains (2) summary
    PTZ00121
    Location:216 → 540
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:532 → 587
    INCENP_ARK-bind; Inner centromere protein, ARK binding region

  2. NM_001306434.3 → NP_001293363.1  Inner centromere protein ARK-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M920
    Conserved Domains (2) summary
    PTZ00121
    Location:165 → 489
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:481 → 536
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
Nucleotide Protein
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