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zwl-1 Protein zwilch homolog [ Caenorhabditis elegans ]

Gene ID: 171798, updated on 2-Nov-2024

Summary

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Official Symbol
zwl-1
Official Full Name
Protein zwilch homolog
Primary source
WormBase:WBGene00021460
Locus tag
CELE_Y39G10AR.2
See related
AllianceGenome:WB:WBGene00021460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of mitotic spindle pole body separation; positive regulation of protein localization to kinetochore; and protein localization to kinetochore involved in kinetochore assembly. Located in kinetochore. Part of RZZ complex. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zwl-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (2402230..2409999)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Synaptic defective enhancer 1 Neighboring gene Histone-lysine N-methyltransferase, H3 lysine-79 specific Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene Electron transfer flavoprotein subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. Henen MA, et al. J Mol Biol, 2021 Feb 19. PMID 33450249, Free PMC Article
  2. Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment. Pereira C, et al. Curr Biol, 2018 Nov 5. PMID 30415699, Free PMC Article
  3. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. Gama JB, et al. J Cell Biol, 2017 Apr 3. PMID 28320824, Free PMC Article
  4. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Dumont J, et al. Nat Cell Biol, 2010 Sep. PMID 20729837, Free PMC Article
  5. Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes. Pitayu-Nugroho L, et al. Nat Commun, 2023 Jul 7. PMID 37419936, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic spindle pole body separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic spindle pole body separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to kinetochore IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore involved in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RZZ complex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein zwilch homolog
NP_001249150.1
  • Confirmed by transcript evidence
NP_001249151.1
  • Confirmed by transcript evidence
NP_001293318.1
  • Confirmed by transcript evidence
NP_001293319.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2402230..2409999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001262222.4 → NP_001249151.1  Protein zwilch homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XP9
    Conserved Domains (1) summary
    pfam09817
    Location:27 → 628
    DUF2352; Uncharacterized conserved protein (DUF2352)

  2. NM_001262221.3 → NP_001249150.1  Protein zwilch homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249150.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A061AD83, A0A061AEC9, H2KZV1, Q95XP9
    Conserved Domains (1) summary
    pfam09817
    Location:27 → 630
    DUF2352; Uncharacterized conserved protein (DUF2352)

  3. NM_001306389.3 → NP_001293318.1  Protein zwilch homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XP9
    Conserved Domains (1) summary
    pfam09817
    Location:7 → 309
    DUF2352; Uncharacterized conserved protein (DUF2352)

  4. NM_001306390.3 → NP_001293319.1  Protein zwilch homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293319.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XP9
    Conserved Domains (1) summary
    pfam09817
    Location:7 → 307
    DUF2352; Uncharacterized conserved protein (DUF2352)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XP9.1

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