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did-2 Charged multivesicular body protein 1b [ Caenorhabditis elegans ]

Gene ID: 171801, updated on 2-Nov-2024

Summary

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Official Symbol
did-2
Official Full Name
Charged multivesicular body protein 1b
Primary source
WormBase:WBGene00017735
Locus tag
CELE_F23C8.6
See related
AllianceGenome:WB:WBGene00017735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Located in endosome membrane. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human CHMP1B (charged multivesicular body protein 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See did-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (2420834..2421816, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene Electron transfer flavoprotein subunit beta Neighboring gene Tyrosine-protein kinase Neighboring gene non-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV. Huynh JM, et al. Genetics, 2016 Feb. PMID 26596346, Free PMC Article
  2. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
  3. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
  4. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in endosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Charged multivesicular body protein 1b
NP_490974.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2420834..2421816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058573.6 → NP_490974.1  Charged multivesicular body protein 1b [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXI3
    Conserved Domains (1) summary
    cl21588
    Location:16 → 181
    Snf7; Snf7
Nucleotide Protein
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