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abtm-1 ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 171807, updated on 2-Nov-2024

Summary

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Official Symbol
abtm-1
Official Full Name
ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial
Primary source
WormBase:WBGene00022281
Locus tag
CELE_Y74C10AR.3
See related
AllianceGenome:WB:WBGene00022281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. Is expressed in coelomocyte; hypodermis; intestine; and spermatheca. Used to study X-linked sideroblastic anemia with ataxia. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abtm-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (2472060..2485391, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Innexin-19 Neighboring gene Transmembrane protein 50A Neighboring gene Conserved secreted protein Neighboring gene Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein Neighboring gene ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans. González-Cabo P, et al. J Biol Chem, 2011 Jun 17. PMID 21464130, Free PMC Article
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial
NP_001021830.1
  • Confirmed by transcript evidence
NP_001293306.1
  • Partially confirmed by transcript evidence
NP_001380172.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2472060..2485391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026659.3 → NP_001021830.1  Iron-sulfur clusters transporter ABCB7, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021830.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SRS5, Q3V5J1, Q71JP9
    Conserved Domains (3) summary
    COG5265
    Location:172 → 667
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:104 → 387
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:437 → 670
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001306377.3 → NP_001293306.1  ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJH7
    Conserved Domains (1) summary
    cl21455
    Location:1 → 60
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001393067.1 → NP_001380172.1  ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACG9, Q71JP8
    Conserved Domains (2) summary
    cd07346
    Location:103 → 126
    ABC_6TM_exporters; TM helix 1 [structural motif]
    cl38913
    Location:103 → 140
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
Nucleotide Protein
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