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ctn-1 Alpha-catulin [ Caenorhabditis elegans ]

Gene ID: 171818, updated on 2-Nov-2024

Summary

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Official Symbol
ctn-1
Official Full Name
Alpha-catulin
Primary source
WormBase:WBGene00000832
Locus tag
CELE_Y23H5A.5
See related
AllianceGenome:WB:WBGene00000832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Is expressed in body wall musculature; muscle cell; neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ctn-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (2606741..2617360)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Protein pid-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans. Abraham LS, et al. PLoS Genet, 2010 Aug 26. PMID 20865173, Free PMC Article
  2. α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. Chen B, et al. EMBO J, 2010 Sep 15. PMID 20700105, Free PMC Article
  3. Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels. Oh KH, et al. BMC Neurosci, 2015 Apr 24. PMID 25907097, Free PMC Article
  4. Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle. Oh HJ, et al. J Biol Chem, 2012 Jun 22. PMID 22577143, Free PMC Article
  5. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles. Mueller BD, et al. Elife, 2023 Feb 23. PMID 36820519, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation
    Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
  2. An Ctn-1 controls neuromuscular function through localization of the dystrophin complex and SLO-1 channels.
    Title: An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Alpha-catulin
NP_001364770.1
  • Partially confirmed by transcript evidence
NP_001379944.1
  • Confirmed by transcript evidence
NP_740814.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2606741..2617360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377804.1 → NP_001364770.1  Alpha-catulin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0F189, H2L011, Q8MPQ6
    Conserved Domains (1) summary
    pfam01044
    Location:114 → 751
    Vinculin; Vinculin family

  2. NM_001393087.1 → NP_001379944.1  Alpha-catulin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0F189, G8JYB2, Q8MPQ6
    Conserved Domains (1) summary
    pfam01044
    Location:100 → 730
    Vinculin; Vinculin family

  3. NM_170830.6 → NP_740814.2  Alpha-catulin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740814.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3U1
    Conserved Domains (1) summary
    pfam01044
    Location:100 → 526
    Vinculin; Vinculin family

RNA

  1. NR_131363.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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