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Matn4 matrilin 4 [ Mus musculus (house mouse) ]

Gene ID: 17183, updated on 28-Oct-2024

Summary

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Official Symbol
Matn4provided by MGI
Official Full Name
matrilin 4provided by MGI
Primary source
MGI:MGI:1328314
See related
Ensembl:ENSMUSG00000016995 AllianceGenome:MGI:1328314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
matrilin-4
Summary
Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within response to axon injury. Located in collagen-containing extracellular matrix. Part of matrilin complex. Is expressed in several structures, including brain; heart; respiratory system; sensory organ; and skeletal system. Orthologous to human MATN4 (matrilin 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in limb E14.5 (RPKM 116.8), lung adult (RPKM 38.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Matn4 in Genome Data Viewer
Location:
2 H3; 2 85.16 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164231313..164247080, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164389393..164405160, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 5 Neighboring gene microRNA 7678 Neighboring gene STARR-seq mESC enhancer starr_06324 Neighboring gene secretory leukocyte peptidase inhibitor Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Matrilin-4, a new member of the matrilin family of extracellular matrix proteins. Wagener R, et al. FEBS Lett, 1998 Sep 25. PMID 9771906
  2. Genomic organisation, alternative splicing and primary structure of human matrilin-4. Wagener R, et al. FEBS Lett, 1998 Nov 6. PMID 9827539
  3. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. Groma G, et al. Matrix Biol, 2011 May. PMID 21539915
  4. Expression of matrilins during maturation of mouse skeletal tissues. Klatt AR, et al. Matrix Biol, 2002 Apr. PMID 12009334
  5. Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. Li P, et al. Int J Mol Sci, 2020 Jan 19. PMID 31963938, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Matn4 and cytokine receptor CXCR4 involved in the regulation of hematopoietic stem cell proliferation and expansion under acute stress.
    Title: Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4.
  2. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state
    Title: Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
  3. Expression of matrilin-4 during maturation of mouse skeletal tissues
    Title: Expression of matrilins during maturation of mouse skeletal tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to axon injury IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of matrilin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
matrilin-4
Names
MAT-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252563.1 → NP_001239492.1  matrilin-4 precursor

    See identical proteins and their annotated locations for NP_001239492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK041073, AL590429, BC036558
    Consensus CDS
    CCDS17034.1
    UniProtKB/Swiss-Prot
    O89029, O89030, Q9QWS3
    UniProtKB/TrEMBL
    F2Z3U4
    Related
    ENSMUSP00000099393.2, ENSMUST00000103104.2
    Conserved Domains (2) summary
    cd01475
    Location:33 → 255
    vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
    pfam14670
    Location:262 → 297
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. NM_013592.4 → NP_038620.2  matrilin-4 precursor

    See identical proteins and their annotated locations for NP_038620.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK041073, AL590429
    Consensus CDS
    CCDS17034.1
    UniProtKB/Swiss-Prot
    O89029, O89030, Q9QWS3
    UniProtKB/TrEMBL
    F2Z3U4
    Related
    ENSMUSP00000099392.4, ENSMUST00000103103.10
    Conserved Domains (2) summary
    cd01475
    Location:33 → 255
    vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
    pfam14670
    Location:262 → 297
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164231313..164247080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89029.1 GenPept UniProtKB/Swiss-Prot:O89029

Gene LinkOut

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