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pph-7 Tyrosine-protein phosphatase [ Caenorhabditis elegans ]

Gene ID: 171861, updated on 2-Nov-2024

Summary

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Official Symbol
pph-7
Official Full Name
Tyrosine-protein phosphatase
Primary source
WormBase:WBGene00022110
Locus tag
CELE_Y71F9AL.4
See related
AllianceGenome:WB:WBGene00022110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pph-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (2903635..2907757)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coatomer subunit alpha Neighboring gene maleylacetoacetate isomerase Neighboring gene Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tyrosine-protein phosphatase
NP_491071.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2903635..2907757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058670.8 → NP_491071.1  Tyrosine-protein phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4H5
    Conserved Domains (2) summary
    smart00194
    Location:177 → 428
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:199 → 428
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
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