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dnj-28 J domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171870, updated on 2-Nov-2024

Summary

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Official Symbol
dnj-28
Official Full Name
J domain-containing protein
Primary source
WormBase:WBGene00001046
Locus tag
CELE_Y54E10BL.4
See related
AllianceGenome:WB:WBGene00001046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Acts upstream of or within PERK-mediated unfolded protein response. Predicted to be active in endoplasmic reticulum. Is expressed in head; hypodermis; intestine; and tail. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-28 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (2996488..3001382)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene small monomeric GTPase Neighboring gene SUPpressor of Rpm-1 Neighboring gene NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Neighboring gene CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone Neighboring gene Dual specificity mitogen-activated protein kinase kinase mek-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. Shemesh N, et al. Nat Commun, 2021 Apr 12. PMID 33846299, Free PMC Article
  2. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. Gaiser AM, et al. J Mol Biol, 2009 Aug 21. PMID 19559711
  3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within PERK-mediated unfolded protein response HEP PubMed 
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
J domain-containing protein
NP_491084.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2996488..3001382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058683.5 → NP_491084.1  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3E0
    Conserved Domains (6) summary
    COG0484
    Location:378 → 445
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:28 → 52
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:380 → 445
    DnaJ; DnaJ domain
    pfam00515
    Location:31 → 56
    TPR_1; Tetratricopeptide repeat
    pfam13371
    Location:78 → 136
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:23 → 89
    TPR_11; TPR repeat
Nucleotide Protein
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