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rpb-7 DNA-directed RNA polymerase II subunit RPB7 [ Caenorhabditis elegans ]

Gene ID: 171877, updated on 2-Nov-2024

Summary

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Official Symbol
rpb-7
Official Full Name
DNA-directed RNA polymerase II subunit RPB7
Primary source
WormBase:WBGene00021845
Locus tag
CELE_Y54E10BR.6
See related
AllianceGenome:WB:WBGene00021845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable single-stranded DNA binding activity; single-stranded RNA binding activity; and translation initiation factor binding activity. Predicted to be involved in regulation of gene expression and transcription initiation at RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II, core complex. Predicted to be active in P-body. Orthologous to human POLR2G (RNA polymerase II subunit G). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpb-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (3031338..3032938, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RNA-binding protein NOB1 Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Signal peptidase complex catalytic subunit SEC11 Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene Transporter Neighboring gene C2H2-type domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
  2. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase II subunit RPB7
NP_491093.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3031338..3032938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058692.7 → NP_491093.1  DNA-directed RNA polymerase II subunit RPB7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3C9
    Conserved Domains (1) summary
    PTZ00162
    Location:24 → 192
    PTZ00162; DNA-directed RNA polymerase II subunit 7; Provisional
Nucleotide Protein
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