nhr-64 Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-64
Official Full Name: Nuclear hormone receptor family member nhr-64
Primary source: WormBase:WBGene00003654
Locus tag: CELE_C45E1.1
See related: AllianceGenome:WB:WBGene00003654
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-64 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (3101983..3109530)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NHR-64 is an important regulator of fat storage in C. elegans
Title: The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C45E1.1 (e-PCR)
- UniSTS:319132

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-64

NP_001021042.2

Confirmed by transcript evidence

NP_001021043.2

Confirmed by transcript evidence

NP_001343721.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3101983..3109530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356801.3 → NP_001343721.1 Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2W7

Conserved Domains (2) summary

cd06960
Location:33 → 108

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

cl11397
Location:132 → 354

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001025871.7 → NP_001021042.2 Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021042.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D4YW56, D4YW57, O44960, Q688B5, Q86PK4, Q86PK5, Q86PK6

Conserved Domains (2) summary

cd06960
Location:27 → 102

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

cl11397
Location:126 → 348

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001025872.7 → NP_001021043.2 Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021043.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O44960

Conserved Domains (2) summary

cd06960
Location:27 → 77

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

cl11397
Location:101 → 323

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators