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edc-4 FHA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171907, updated on 2-Nov-2024

Summary

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Official Symbol
edc-4
Official Full Name
FHA domain-containing protein
Primary source
WormBase:WBGene00021551
Locus tag
CELE_Y44E3A.6
See related
AllianceGenome:WB:WBGene00021551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in cytoplasm. Predicted to be active in P-body. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See edc-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (3340212..3349914, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Thioredoxin Neighboring gene SH3 domain-containing protein Neighboring gene Creatinase_N domain-containing protein;Hydrolase;Uncharacterized protein Neighboring gene Hyphal_reg_CWP domain-containing protein Neighboring gene AGC-kinase C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization. Vidya E, et al. Cell Rep, 2024 Oct 22. PMID 39331503
  2. PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Kiefer JC, et al. Dev Biol, 2007 Mar 15. PMID 17250823, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.
    Title: EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FHA domain-containing protein
NP_001391101.1
  • Confirmed by transcript evidence
NP_001391102.1
  • Confirmed by transcript evidence
NP_740827.1
  • Confirmed by transcript evidence
NP_740828.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3340212..3349914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170842.7 → NP_740827.1  FHA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8ITV7
    Conserved Domains (1) summary
    pfam16529
    Location:52 → 377
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein

  2. NM_001404253.1 → NP_001391102.1  FHA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QCB9

  3. NM_171835.7 → NP_740828.1  FHA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8ITV6
    Conserved Domains (1) summary
    pfam16529
    Location:52 → 377
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein

  4. NM_001404249.1 → NP_001391101.1  FHA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBN9
Nucleotide Protein
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