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pcaf-1 Histone acetyltransferase GCN5 [ Caenorhabditis elegans ]

Gene ID: 171920, updated on 2-Nov-2024

Summary

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Official Symbol
pcaf-1
Official Full Name
Histone acetyltransferase GCN5
Primary source
WormBase:WBGene00021636
Locus tag
CELE_Y47G6A.6
See related
AllianceGenome:WB:WBGene00021636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3 acetyltransferase activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleus. Predicted to be part of ATAC complex. Orthologous to several human genes including KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pcaf-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (3516450..3523418)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sugar phosphate transporter domain-containing protein Neighboring gene ncRNA Neighboring gene Golgi phosphoprotein 3 homolog sauron Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene 40S ribosomal protein S19-binding protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential chromatin marking of introns and expressed exons by H3K36me3. Kolasinska-Zwierz P, et al. Nat Genet, 2009 Mar. PMID 19182803, Free PMC Article
  2. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Shibata Y, et al. Development, 2010 Apr. PMID 20181741
  3. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans. Victor M, et al. EMBO Rep, 2002 Jan. PMID 11751575, Free PMC Article
  4. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol CJ, et al. Dev Cell, 2004 Apr. PMID 15068795
  5. The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells. Lin B, et al. Dev Biol, 2008 Apr 1. PMID 18304523, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone acetyltransferase GCN5
NP_491173.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3516450..3523418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058772.8 → NP_491173.1  Histone acetyltransferase GCN5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3S7
    Conserved Domains (4) summary
    cd05509
    Location:650 → 748
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:408 → 735
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:476 → 544
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:9 → 247
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
Nucleotide Protein
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