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rnp-6 Poly(U)-binding-splicing factor rnp-6 [ Caenorhabditis elegans ]

Gene ID: 171922, updated on 2-Nov-2024

Summary

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Official Symbol
rnp-6
Official Full Name
Poly(U)-binding-splicing factor rnp-6
Primary source
WormBase:WBGene00004389
Locus tag
CELE_Y47G6A.20
See related
AllianceGenome:WB:WBGene00004389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; mRNA splice site recognition; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Orthologous to human PUF60 (poly(U) binding splicing factor 60). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rnp-6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (3539553..3546910, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene 40S ribosomal protein S19-binding protein 1 Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene RNA interference defective protein 10 Neighboring gene DeHydrogenases, Short chain Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60. Kew C, et al. Elife, 2020 Jun 15. PMID 32538777, Free PMC Article
  2. PUF60: a novel U2AF65-related splicing activity. Page-McCaw PS, et al. RNA, 1999 Dec. PMID 10606266, Free PMC Article
  3. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Wueseke O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103243, Free PMC Article
  4. Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity. Huang W, et al. Nat Aging, 2022 Sep. PMID 37118503, Free PMC Article
  5. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60.
    Title: Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Poly(U)-binding-splicing factor rnp-6
NP_001360094.1
  • Confirmed by transcript evidence
NP_491176.1
  • Confirmed by transcript evidence
NP_740829.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3539553..3546910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058775.8 → NP_491176.1  Poly(U)-binding-splicing factor rnp-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491176.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXS9, Q9N3S3, Q9N3S4
    Conserved Domains (1) summary
    TIGR01645
    Location:5 → 749
    half-pint; poly-U binding splicing factor, half-pint family

  2. NM_001373813.2 → NP_001360094.1  Poly(U)-binding-splicing factor rnp-6 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    TIGR01645
    Location:5 → 338
    half-pint; poly-U binding splicing factor, half-pint family

  3. NM_170843.5 → NP_740829.1  Poly(U)-binding-splicing factor rnp-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740829.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXS9
    Conserved Domains (2) summary
    cd12370
    Location:102 → 177
    RRM1_PUF60; RNA recognition motif 1 in (U)-binding-splicing factor PUF60 and similar proteins
    cd12371
    Location:207 → 279
    RRM2_PUF60; RNA recognition motif 2 in (U)-binding-splicing factor PUF60 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N3S4.1

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