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mis-12 uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 171927, updated on 2-Nov-2024

Summary

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Official Symbol
mis-12
Official Full Name
uncharacterized protein
Primary source
WormBase:WBGene00021648
Locus tag
CELE_Y47G6A.24
See related
AllianceGenome:WB:WBGene00021648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in kinetochore assembly. Located in kinetochore. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mis-12 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (3604515..3605744, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Innexin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Welburn JP, et al. Mol Cell, 2010 May 14. PMID 20471944, Free PMC Article
  2. MEL-28/ELYS and CENP-C coordinately control outer kinetochore assembly and meiotic chromosome-microtubule interactions. Hattersley N, et al. Curr Biol, 2022 Jun 6. PMID 35609608, Free PMC Article
  3. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Gerson-Gurwitz A, et al. Cell, 2016 Apr 7. PMID 27020753, Free PMC Article
  4. Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A in Caenorhabditis elegans. Lange KI, et al. Genetics, 2019 Jun. PMID 31018924, Free PMC Article
  5. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Monen J, et al. Nat Cell Biol, 2005 Dec. PMID 16273096

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_001122540.1
  • Product from WormBase gene class mis;
    Partially confirmed by transcript evidence; human/fission yeast MIS (MInichromosome Stability) homolog
NP_491184.1
  • Product from WormBase gene class mis;
    Partially confirmed by transcript evidence; human/fission yeast MIS (MInichromosome Stability) homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3604515..3605744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058783.9 → NP_491184.1  uncharacterized protein CELE_Y47G6A.24 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3R7

  2. NM_001129068.4 → NP_001122540.1  uncharacterized protein CELE_Y47G6A.24 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0D9
    Conserved Domains (1) summary
    pfam05859
    Location:16 → 127
    Mis12; Mis12 protein
Nucleotide Protein
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