ftn-2 Ferritin [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ftn-2
Official Full Name: Ferritin
Primary source: WormBase:WBGene00001501
Locus tag: CELE_D1037.3
See related: AllianceGenome:WB:WBGene00001501
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in basal ganglia disease; hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegenerative disease (multiple). Orthologous to several human genes including FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_491198.1

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The following sections contain reference sequences that belong to a specific genome build. Explain