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hus-1 Checkpoint protein [ Caenorhabditis elegans ]

Gene ID: 171939, updated on 2-Nov-2024

Summary

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Official Symbol
hus-1
Official Full Name
Checkpoint protein
Primary source
WormBase:WBGene00002042
Locus tag
CELE_H26D21.1
See related
AllianceGenome:WB:WBGene00002042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including DNA metabolic process; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromatin and germ cell nucleus. Is expressed in germ line. Orthologous to several human genes including HUS1B (HUS1 checkpoint clamp component B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hus-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (3698102..3699300)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DNA mismatch repair proteins mutS family domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects induced by keV low-energy ion irradiation in the nematode Caenorhabditis elegans. Liu X, et al. Radiat Environ Biophys, 2007 Aug. PMID 17380344
  2. Synergistic effects induced by a low dose of diesel particulate extract and ultraviolet-A in Caenorhabditis elegans: DNA damage-triggered germ cell apoptosis. Guo X, et al. Chem Res Toxicol, 2014 Jun 16. PMID 24841043, Free PMC Article
  3. Nickel-induced apoptosis and relevant signal transduction pathways in Caenorhabditis elegans. Cai Kezhou, et al. Toxicol Ind Health, 2010 May. PMID 20237193
  4. Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans : A Unique Role of the DNA Damage Checkpoint. Tang H, et al. Radiat Res, 2016 Dec. PMID 27874324
  5. Reproductive toxicity by exposure to low concentrations of pesticides in Caenorhabditis elegans. Moya A, et al. Toxicology, 2022 Jun 15. PMID 35697162

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA damage checkpoint protein hus-1 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells.
    Title: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
  2. required for DNA damage-induced cell cycle arrest and apoptosis
    Title: Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA integrity checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Checkpoint protein
NP_491203.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3698102..3699300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058802.7 → NP_491203.1  Checkpoint protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFI9
    Conserved Domains (1) summary
    pfam04005
    Location:1 → 272
    Hus1; Hus1-like protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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