unc-108 Ras-related protein Rab-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-108
Official Full Name: Ras-related protein Rab-2
Primary source: WormBase:WBGene00006833
Locus tag: CELE_F53F10.4
See related: AllianceGenome:WB:WBGene00006833
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activity. Involved in several processes, including dense core granule maturation; phagosome maturation involved in apoptotic cell clearance; and regulation of locomotion involved in locomotory behavior. Located in several cellular components, including Golgi apparatus subcompartment; cytoplasmic vesicle; and neuronal cell body. Is expressed in several structures, including excretory gland cell; hermaphrodite somatic gonadal cell; intestine; neurons; and pharynx. Orthologous to several human genes including RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-108 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (3822883..3826514)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gop-1 as a novel regulator of apoptotic cell clearance in Caenorhabditis elegans via activation of Rab2.
Title: GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.
UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.
Title: UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.
Report impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2.
Title: Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2.
UNC-108/Rab2 regulates postendocytic trafficking, most likely at the level of early or recycling endosomes, and UNC-108/Rab2 and the MVB pathway define alternative postendocytic trafficking mechanisms that operate in parallel
Title: UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans.
UNC-108 co-localizes with RAB-5, RAB-7 and LMP-1 to the phagosome and promotes cell corpse degradation, possibly by mediating phagosome maturation.
Title: C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells.
unc-108 acts in neurons and engulfing cells to control locomotion and cell corpse removal, respectively, indicating that unc-108 has distinct functions in different cell types.
Title: The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53F10.4 (e-PCR)
- UniSTS:315903

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IC Inferred by Curator more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dense core granule maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagolysosome assembly involved in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagolysosome assembly involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome acidification involved in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagosome acidification involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi trans cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-related protein Rab-2

NP_001343725.1

Confirmed by transcript evidence

NP_001343726.1

Confirmed by transcript evidence

NP_001343727.1

Confirmed by transcript evidence

NP_001379759.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3822883..3826514

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356804.3 → NP_001343725.1 Ras-related protein Rab-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2Y0, I7FN62

Conserved Domains (1) summary

cl27030
Location:10 → 202

Ras; Ras family
NM_001393282.1 → NP_001379759.1 Ras-related protein Rab-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

I7FN62, O01577

Conserved Domains (1) summary

PLN03108
Location:1 → 193

PLN03108; Rab family protein; Provisional
NM_001356805.3 → NP_001343726.1 Ras-related protein Rab-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3C9

Conserved Domains (1) summary

cl27030
Location:1 → 147

Ras; Ras family
NM_001356806.3 → NP_001343727.1 Ras-related protein Rab-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C379

Conserved Domains (1) summary

cl27030
Location:1 → 48

Ras; Ras family