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coq-4 Ubiquinone biosynthesis protein coq-4, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 171966, updated on 17-Oct-2024

Summary

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Official Symbol
coq-4
Official Full Name
Ubiquinone biosynthesis protein coq-4, mitochondrial
Primary source
WormBase:WBGene00000764
Locus tag
CELE_T03F1.2
See related
AllianceGenome:WB:WBGene00000764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See coq-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3869214..3870114)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HoloCentric chromosome binding Protein Neighboring gene putative phosphoglycerate kinase Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans ubiquinone biosynthesis genes. Rodríguez-Aguilera JC, et al. Biofactors, 2003. PMID 14695939
  2. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J, 2003 Jun. PMID 12709403
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquinone biosynthesis protein coq-4, mitochondrial
NP_491246.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3869214..3870114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058845.5 → NP_491246.4  Ubiquinone biosynthesis protein coq-4, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491246.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91428
    Conserved Domains (1) summary
    pfam05019
    Location:15 → 227
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91428.2

Gene LinkOut

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