E01A2.1 GCS light chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: E01A2.1
Official Full Name: GCS light chain
Primary source: WormBase:WBGene00017084
Locus tag: CELE_E01A2.1
See related: AllianceGenome:WB:WBGene00017084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate-cysteine ligase catalytic subunit binding activity and glutamate-cysteine ligase regulator activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See E01A2.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (4139558..4142367)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E01A2.i (e-PCR)
- UniSTS:323548

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutamate-cysteine ligase catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables glutamate-cysteine ligase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of glutamate-cysteine ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GCS light chain

NP_001367719.1

Confirmed by transcript evidence

NP_001379848.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4139558..4142367

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379700.1 → NP_001367719.1 GCS light chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A9CZN9

Conserved Domains (1) summary

cl00470
Location:92 → 224

AKR_SF; Aldo-keto reductase (AKR) superfamily
NM_001392097.1 → NP_001379848.1 GCS light chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q966L2

Conserved Domains (1) summary

cl00470
Location:78 → 210

AKR_SF; Aldo-keto reductase (AKR) superfamily