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poml-2 Arylesterase [ Caenorhabditis elegans ]

Gene ID: 171999, updated on 2-Nov-2024

Summary

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Official Symbol
poml-2
Official Full Name
Arylesterase
Primary source
WormBase:WBGene00017089
Locus tag
CELE_E01A2.7
See related
AllianceGenome:WB:WBGene00017089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable arylesterase activity and metal ion binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See poml-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (4142282..4144583, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Akirin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GCS light chain Neighboring gene SMP-30/Gluconolactonase/LRE-like region domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables arylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arylesterase
NP_491306.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4142282..4144583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058905.5 → NP_491306.1  Arylesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q966L1
    Conserved Domains (2) summary
    COG3386
    Location:110 → 283
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cl22863
    Location:166 → 245
    Str_synth; Strictosidine synthase
Nucleotide Protein
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