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R12E2.11 Orotate phosphoribosyltransferase [ Caenorhabditis elegans ]

Gene ID: 172008, updated on 2-Nov-2024

Summary

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Official Symbol
R12E2.11
Official Full Name
Orotate phosphoribosyltransferase
Primary source
WormBase:WBGene00020036
Locus tag
CELE_R12E2.11
See related
AllianceGenome:WB:WBGene00020036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables orotate phosphoribosyltransferase activity. Involved in UMP biosynthetic process. Is expressed in body wall musculature; intestine; spermatheca; and vulval muscle. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See R12E2.11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (4172438..4173624, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inactive protein-tyrosine phosphatase egg-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein bS6m Neighboring gene MPN domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. Kim S, et al. FEBS J, 2009 Sep. PMID 19645718
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Orotate phosphoribosyltransferase
NP_491317.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4172438..4173624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058916.6 → NP_491317.1  Orotate phosphoribosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491317.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61790
    Conserved Domains (1) summary
    COG0461
    Location:32 → 221
    PyrE; Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61790.1

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