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eif-3.H Eukaryotic translation initiation factor 3 subunit H [ Caenorhabditis elegans ]

Gene ID: 172044, updated on 2-Nov-2024

Summary

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Official Symbol
eif-3.H
Official Full Name
Eukaryotic translation initiation factor 3 subunit H
Primary source
WormBase:WBGene00001231
Locus tag
CELE_C41D11.2
See related
AllianceGenome:WB:WBGene00001231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metallopeptidase activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including enteric muscle; excretory cell; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eif-3.H in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (4444719..4446613)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Neighboring gene Endonuclease G, mitochondrial Neighboring gene TM2 domain-containing protein C41D11.9 Neighboring gene Protein cmt-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen identifies C. elegans eif-3.H and hrpr-1 as pro-apoptotic genes and potential activators of egl-1 expression. Jiang Y, et al. MicroPubl Biol, 2024. PMID 38434221, Free PMC Article
  2. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
  3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 3 subunit H
NP_491370.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4444719..4446613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058969.5 → NP_491370.1  Eukaryotic translation initiation factor 3 subunit H [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01974
    Conserved Domains (1) summary
    cd08065
    Location:13 → 296
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01974.2

Gene LinkOut

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