unc-57 Endophilin-A homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-57
Official Full Name: Endophilin-A homolog
Primary source: WormBase:WBGene00006791
Locus tag: CELE_T04D1.3
See related: AllianceGenome:WB:WBGene00006791
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in clathrin-dependent endocytosis and necroptotic process. Located in neuromuscular junction. Is expressed in several structures, including coelomocyte; hermaphrodite gonad; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2); SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); and SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-57 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (4675133..4679448)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the membrane-bending activity is essential for unc-57 endophilin's function and that endophilin undergoes an association-dissociation cycle with SVs that parallels the cycle of exo- and endocytosis.
Title: Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04D1.3 (e-PCR)
- UniSTS:314878

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle uncoating	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Endophilin-A homolog

NP_001040680.1

Confirmed by transcript evidence

NP_001040681.1

Confirmed by transcript evidence

NP_001122512.1

Confirmed by transcript evidence

NP_001122513.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4675133..4679448

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129040.5 → NP_001122512.1 Endophilin-A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122512.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B1V8A0

Conserved Domains (2) summary

cd07592
Location:25 → 245

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:321 → 375

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
NM_001129041.3 → NP_001122513.1 Endophilin-A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122513.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5A8Q9, A5A8R0, B1V8A0, O61843, Q6TM46

Conserved Domains (2) summary

cd07592
Location:25 → 245

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:323 → 377

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
NM_001047215.5 → NP_001040680.1 Endophilin-A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040680.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B1V8A0

Conserved Domains (2) summary

cd07592
Location:25 → 245

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:319 → 373

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
NM_001047216.3 → NP_001040681.1 Endophilin-A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040681.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B1V8A0

Conserved Domains (1) summary

cd11803
Location:44 → 98

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A