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kca-1 Kinesin Cargo Adaptor [ Caenorhabditis elegans ]

Gene ID: 172090, updated on 2-Nov-2024

Summary

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Official Symbol
kca-1
Official Full Name
Kinesin Cargo Adaptor
Primary source
WormBase:WBGene00015698
Locus tag
CELE_C10H11.10
See related
AllianceGenome:WB:WBGene00015698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables kinesin binding activity. Involved in embryo development; establishment of meiotic spindle localization; and polar body extrusion after meiotic divisions. Part of kinesin I complex. Is expressed in gonad and oocyte. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kca-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (4759820..4761321, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HP domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Centriole engagement: it's not just cohesin any more. Sluder G. Curr Biol, 2013 Aug 5. PMID 23928085
  2. Kinesin-dependent transport results in polarized migration of the nucleus in oocytes and inward movement of yolk granules in meiotic embryos. McNally KL, et al. Dev Biol, 2010 Mar 1. PMID 20036653, Free PMC Article
  3. Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Ellefson ML, et al. Mol Biol Cell, 2009 Jun. PMID 19357192, Free PMC Article
  4. Asymmetric division: a kinesin for spindle positioning. McCarthy EK, et al. Curr Biol, 2005 Aug 9. PMID 16085478
  5. Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. Yang HY, et al. J Cell Biol, 2005 May 9. PMID 15883196, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of meiotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of kinesin I complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Kinesin Cargo Adaptor
NP_491443.3
  • Product from WormBase gene class kca;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4759820..4761321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059042.6 → NP_491443.3  Kinesin Cargo Adaptor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491443.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBU5
Nucleotide Protein
Heading Accession and Version

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