him-1 Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: him-1
Official Full Name: Structural maintenance of chromosomes protein 1
Primary source: WormBase:WBGene00001860
Locus tag: CELE_F28B3.7
See related: AllianceGenome:WB:WBGene00001860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA binding activity. Involved in several processes, including chromosome segregation; response to UV; and response to X-ray. Located in chromatin and nucleus. Part of cohesin complex. Is expressed in germ line; linker cell; and somatic cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to several human genes including SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See him-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (4951571..4957667, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28B3.7 (e-PCR)
- UniSTS:306206

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cohesin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cohesin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Structural maintenance of chromosomes protein 1

NP_001040658.2

Confirmed by transcript evidence

NP_001040659.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4951571..4957667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047193.6 → NP_001040658.2 Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040658.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01789, Q2A957

Conserved Domains (1) summary

pfam02463
Location:15 → 1232

SMC_N; RecF/RecN/SMC N terminal domain
NM_001047194.3 → NP_001040659.1 Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040659.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01789

Conserved Domains (2) summary

cd03275
Location:15 → 118

ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins

pfam02463
Location:1 → 110

SMC_N; RecF/RecN/SMC N terminal domain