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him-1 Structural maintenance of chromosomes protein 1 [ Caenorhabditis elegans ]

Gene ID: 172116, updated on 2-Nov-2024

Summary

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Official Symbol
him-1
Official Full Name
Structural maintenance of chromosomes protein 1
Primary source
WormBase:WBGene00001860
Locus tag
CELE_F28B3.7
See related
AllianceGenome:WB:WBGene00001860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA binding activity. Involved in several processes, including chromosome segregation; response to UV; and response to X-ray. Located in chromatin and nucleus. Part of cohesin complex. Is expressed in germ line; linker cell; and somatic cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to several human genes including SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See him-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (4951571..4957667, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein Neighboring gene Chloride channel protein CLC-d Neighboring gene Uncharacterized protein Neighboring gene Mitotic spindle organiZing protein (MOZART) homolog Neighboring gene ENhancer of Uncoordination

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm isolation and biochemical analysis of the major sperm protein from Caenorhabditis elegans. Klass MR, et al. Dev Biol, 1981 Jun. PMID 20737868
  2. Centriole engagement: it's not just cohesin any more. Sluder G. Curr Biol, 2013 Aug 5. PMID 23928085
  3. The role of chromosome ends during meiosis in Caenorhabditis elegans. Wicky C, et al. Bioessays, 1996 Jun. PMID 8787533
  4. Chromosome rearrangements in Caenorhabditis elegans. Herman RK, et al. Genetics, 1976 May. PMID 1269921, Free PMC Article
  5. cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis. Stanvitch G, et al. Genetics, 2008 Jan. PMID 18202360, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cohesin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cohesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Structural maintenance of chromosomes protein 1
NP_001040658.2
  • Confirmed by transcript evidence
NP_001040659.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4951571..4957667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047193.6 → NP_001040658.2  Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040658.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01789, Q2A957
    Conserved Domains (1) summary
    pfam02463
    Location:15 → 1232
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001047194.3 → NP_001040659.1  Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01789
    Conserved Domains (2) summary
    cd03275
    Location:15 → 118
    ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
    pfam02463
    Location:1 → 110
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01789.4

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