paf-1 1-alkyl-2-acetylglycerophosphocholine esterase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: paf-1
Official Full Name: 1-alkyl-2-acetylglycerophosphocholine esterase
Primary source: WormBase:WBGene00003906
Locus tag: CELE_W03G9.6
See related: AllianceGenome:WB:WBGene00003906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Involved in lipid catabolic process. Predicted to be located in cytosol and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII) and PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_001379900.1

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